I was living with my grandmother for a bit after getting into some verbal and physical fights with my dad at home.
She is an incredibly devout Catholic. I am not. We were talking about depression a bit one night, and she said something along the lines of "Y'know, I really wish that you had faith in God, because he's the best support structure you'll ever get, and I can't imagine how you get by without having faith in your life." Being a pagan, my reply came as "But I do have faith. Not in God, but my own deities. And they bring me great peace and fulfillment, and I am grateful to them, myself, and others every day. I have great satisfaction in my spirituality already, and I get everything I need from the way I explore it."
Then she paused, stroked her chin for a bit, looked me dead in the eye and said
"I feel sorry for you."
After being very candid about my own personal beliefs, and leaving myself emotionally vulnerable to discuss them, especially after I had explained what that spirituality meant to me, only to have it struck down and dismissed by a loved one, really, really hurt.