"You will be baked, and there will be cake."
GLaDOS in [em]Portal[/em], at the end of the "official" levels
"Muh head hurts, muh feet stank, and I don't love Jesus."
Lester in [em]Redneck Rampage[/em], one of his dying lines
half the things said to or by Roger Wilco in the [em]Space Quest[/em] series
I wish I could remember the many great lines from [em]Arcanum: Of Steamworks and Magick Obscura[/em], but it's been so long since I played that...
"Stop, villain!"
Maybe you had to be there, but when the Teutonic Knights kept shouting that at my party in [em]Vampire: The Masquerade: Redemption[/em], it made me reply aloud, "I'm not Wilhem, I'm Christophe!" Also, anything Dev/Null says. "Pink, Assamite interesting name." "Beep, beep, beep... Ooh, my grits are done!"
"No, [em]you[/em] stop!"
"You have made a powerful enemy today, sign."
From a Malkavian-exclusive dialogue with a stop sign in [em]Vampire: The Masquerade: Bloodlines[/em]. Really, most of the Malkavian's lines are gold, like getting a key from a guard just by saying, "I'm a keyring." No, really.
"Chocolate syrup or peanut butter? Chocolate syrup or peanut butter? Duuude, I've gotta dip these potato chips in something!"
"Dude, where's my car? Wait a minute! I don't even [em]have[/em] a car, dude!"
"Fifty-seven, fifty-eight, fifty-nine... Fifteen more cents and you're going in my stomach, choco bombs!"
Spicoli from [em]Vampire: The Masquerade: Bloodlines[/em]
Anything from [em]Vampire: The Masquerade: Bloodlines[/em] related to the hit game "Don't Touch the Butter" or Frickin' Chicken. "Mmm, that's some good frickin chicken."