Step one is to plant false evidence that Deadpool committed a massacre of unforgivable size, and distribute that so that that evidence will come to light at a future point of my choosing. Once that farce is set up, then phase two happens. Breaking into the abandoned weapon X laboratories, I start with the replicator tubes. Mixing the dna sample of Leech that they have on file with degenerate moloid dna. After getting a mind control tech off the black market so I can control my army of power draining moloid minions that will turn to sludge in a few days once freed from their cells.
While I got the mind control tech out, I'd trick the Weasel into recording a voice message onto a phone that is set up to play at a certain time. Then I could kill Weasel or lock him up.. I dunno.. whichever I feel at the time.
Next comes setting up Deadpool, a murder here a hostage there. Nothing to fancy, I'm not trying to drop the hammer on him, only get the attention of one man, The Punisher. Everyone is waiting for Deadpool to snap anyways, so it wouldn't be to hard to get the Punisher after him. With that in place, and Deadpool preoccupied with the Punisher I unleash my moloids to set in place underneath the streets of Manhattan and lay in wait. I detonate the labs so no evidence I was there can be found, and go to watch the show.
With Deadpool on the run from the Punisher, he'll receive a message from his buddy, that he found out who set him up and he'll need to head to Manhattan to stop this. As the two of them duke it out in the streets, Deadpool'll stand in the spot I told him to be, and the moment they are in place my moloid slaves will break for the surface and wave over the two "heroes". One touch is all I need for Deadpool's healing power to leave him, and there's a lot of hands.
When Deadpool's powers have weakened, I will sit forward and see him shot through the head by his own friend Cable, sent back in time to stop a terrible massacre at any cost. Knowing conventions would send him to this moment, right before the "massacre" would happen. And if not Cable then the Punisher'll finish the job.
No monologue, I just walk away as everyone goes after the moloid army that has begun rampaging through the city, and who's cells will pop in a few hours leaving no evidence there but a sludge of disjointed dna and biomass. Perhaps I'll get a smoothie after to celebrate my own victory.