It bothers me that Yahtzee writes a lot of jokes at the expense of women or anyone who isn't the middle-class, able-bodied, straight, white, cis man. I don't actually know much about Yahtzee's character and I wouldn't assume he's the kind of person that cares if anyone is offended by what he says. I do however know he is an exoerienced writer and as such I would expect him to take some pride in the jokes he writes. Making a joke about a pre-op transexual or having sex with a pre-op transexual is easy because it appeals to the playground humour built on pubescent boys' sexual insecurities and you only have to bring up the image of a man with a penis in his mouth to make the lowest common denominator viewer piss themselves. Generally, good writers find ways of creating comedy that transcend human knee-jerk reactions and I personally apreciate when a writer has assumed that I, the person enjoying their output, is not a club-dragging neanderthal and they attempt comedy with a little more sophistication than "Look at this thing you have been taught to find funny and laugh, sheep".
I reiterate, this has nothing to do with offense, even if that is a can of worms I would be willing to open. This is about being a good writer and creating witty, original humour. I'm not here to speak up for anyone but myself. Jokes about femininity, homosexuality, transexuality, domestic violence, sexual abuse and the ilk are the easy option and unbecoming of anyone who has talent to write better jokes; and, need I say it, have been sufficiently played out over the last few millennia in my opinion.
Believe me, I understand the tight schedule Zero Punctuation has to follow and it is no small task to come up with 50 jokes and fit them in a 5 minute skit every week but as a long-time viewer I would let it be known I'd much prefer 25 curated jokes that didn't involve a penis threatening someone's sexuality or making fun of someone who has done nothing to elicit public ridicule.