That's unlikely in a world without intercontinental travel, but lots of epidemics, almost certainly. And i'm not saying unrecorded, there are hundreds of historically noted waves of disease where we can't actually tell what the disease was looking back. If you look at lists of historical epidemics, the causes may as well be listed as "the hell if we know" until you get to bubonic plague and influenza, and even now researchers are looking back and thinking "actually,
the pandemic in 1899-1890 may have not been the flu, it might have been a coronavirus."