Not for me. I think I only ever got far enough into Code Veronica to see Alfred, and Jesus was that character the absolute worst.I think the Ashford's are the better villains in RE. The siblings certainly leave an impression and the family adds flavor to Umbrella so it wasn't just a faceless corporation doing things seemingly for the hell of it.
Umbrella never needed to have a face, because it worked in making the company feel inculpable and free of consequences from the horrors they created. It felt inhuman, like a real corporation. You can feel Umbrella's presence through their absence as you're making your way through monster infested mansions and police stations, with the people actually running the company likely somewhere safe without a care in the world. Honestly, just a giant, omimous tube with the Umbrella logo on it, likely housing some creature, is enough to get the point across.
Umbrella is ostensibly just a logo and it makes their actions and presence feel far more inhuman and horrifiing than if it was a main bad guy running the show. I guess that might actually be the core reason I don't like Wesker being the main baddie in this franchise.