It would seem the layout was never meant to really mesh with the U.S. entirely due to Roanoke being in the Blue Ridge mountains of Virginia. Other things like Cumberland Falls actually being in Kentucky, whereas in-game it’s west of Valentine which is apparently based off of Valentine, Nebraska.I think it is supposed to be Mexico because it's attached to the desert bits on the left border, though the layout is kinda wierd no matter how you slice it, because St. Denis should be next to the Gulf of Mexico and the Mississippi, so Roanoke Ridge and Van horn should also be approx. around the Mississippi as well.
They took liberties with the layout because even if it was geographically correct, it would bring up the problem of how players could physically traverse the entire U.S. in about twenty minutes or so.
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