I'd actually like the Desmond centric game. It seems the only plausible way to finish the fucking series now, since he's cured from the bleeding effect it might not make any sense for him to go back into the animus. Plus it's not too late to give him a good character. Maybe if he's vengeful, like really pissed off, that's not very strong or good I know I'm just coming up with this on the spot, but yeah it seems the only way for it to make sense.