What I really hate about adaptations and live-actions are the fact there is a language and regional divide. If anyone watches anime, and has seen at least one episode of whatever dubbed and one with translations, then you'll know what I'm talking about. People argue whether dubbed or translated is better for the audience on so many levels. I think whenever there is a transition something is lost. First...
Not in Japanese: Most people can deal with it, but I like to watch a film in it's original language. Not a big deal but still.
Source material: Um, so it's a Japanese manga (comic), that became a Japanese anime movie, which renewed it's own Japanese anime series, and some other little stuff in between. Then Americans are going to port these ideas, characters, and thematic elements into a live-action movie, intended for American views? Sounds a lot of money down the drain.
Japan is not American, no matter how many pseudo-Japanese American there are: If anyone has read a novel, watched a movie/TV series, from another culture let alone another country, you'll realize there are a lot of differences in everything from street slag to politics. I think that the movie will either end sacrificing so much of the source material and the culture behind it, and become something with "Ghost in the Shell" tacked on to it. Or on the rare and strange occasion, it becomes a movie that actually satisfies the fan-base, but would fail to deliver stereotypical effects and scenes (I.E. Exploding cars in blimps on fire with bikinis) that would initially attract the every day American audience. Even more so the more they cater to a fan-bases needs, to more confusing characters, relationships, and the overall plot. Anyone else think if you show a 30 second clip of a Tachikoma talking, in it's child like voice to a highly armed squad of Japanese SWAT, that it would confuse the hell out of most people? The impossible situation is a combination of both to the point where people love it and fans don't cry in anguish, but that's a dream in a dream.
Long story short, Ghost in the Shell live-action adaptation = BAD IDEA