Kid Icarus Uprising with Xenoblade. Now, I know what you're thinking "What kind of a madness filled combination is THAT?!" Well, lemme explain~ Imagine like... a faster travel system than walking (In exchange for normal fast travel), but it takes the rail shooter style of the air combat in Uprising with randomly spawning enemies and such. Then on the ground, it's basically Uprising with RPG elements and bigger, more epic bosses.
I dunno, I've got nothing else in mind XD I love Uprising, so have a huge open world to explore instead of linear levels would be so much fun