I think the change of the last two Horsemen is because to keep it hack&slash.
By default Vigil Games is going backwards in terms of "Power". I.e. War being the strongest of the 4, then Death, then Pestilence, then Famine. Its rather their "Order" as it were, being that War included parts of the other 3. Its rather weird how its written anyway, the Lore itself, not what Vigil Games is using from it.
I would see Pestilence as some sort of "mage"-type character, i.e. slow/fragile but incredibly powerful with Curses and such Stuff. Where as Famine may be used as some kind of "Pet Class", i.e. having Zombies or whatever as his little horde, kinda Overlord Style.
War and Death are basicly the "we can fuck you up" Guys, hence why they kept them since they can keep the game as straightforward hack&slash ala Devil May Cry/God of War. The original other two wouldnt work for it, hence the change, even though if they had kept them, they could have made some interesting Gameplay Variations, i.e. Pestilence being all about Curses and Diseases, gaining power from "corrupting" Things and smacking Dudes from afar. And Famine being a sort of "Yo, here's my little Underling Horde who rips you apart".
Still the trailer looks semi-interesting. Though im not much of a Fan of how they made Death look, given the Style they gave to War, which fit rather well. Death seems like they wanted to keep it like that but went too far any he looks..comical and over-the-top now. Still to me it would be the last Game i'd play given that they changed the last two Horsemen to be something else, which to me has no real relation. I mean Fury and Strife are essentially like parts of War and Death to begin with, so its like a second-hand copy of the first two.