Has already happened for me. I am 30 years old, married, 2 kids(with another planned), and a "career". Mass Effect 3 was to be the last big game for me, and that was only because it was the end of the series. I just don't have the time anymore.
I still play some games, but mostly cheap and short indie titles. Oh, and I got married, had the kids, and started my career Since I played the first Mass Effect, so it was kinda special for me. I didn't let the ending ruin it for me, and appreciated the time I had with the ME universe.
From "Alley Cat" in the 1980s to "Mass Effect 3" in the 2010s. It's been a blast.