As a girl with a rather ample supply, myself, for me it really is about the explanation as to how I feel about them. I watched Bleach and Hallibel was one of my favourite characters, partially because I loved her design (including the F-cup, although I also loved the bone deformation over them acting as a bra, so convenient! I want!), and I don't recall seeing any explanation for her size at all. So I just went with it. My other favourite character was Soifon, who was tiny and basically flat *shrugs*
Similarly, some people have brought up Miranda from ME2... I hated her, don't get me wrong, but that was because she was an awful *****, and I didn't like her outfit, but it wasn't because it was skintight, but because she was wearing goddamn HEELS INTO COMBAT. LIKE A TOTAL MORON WHO WANTS TWO BROKEN ANKLES. They even had an asari character call her a whore for dressing like that in-game, which made me laugh, and seemed to acknowledge the fan-servicey-ness... I dunno. I didn't mind it, possibly more because of that.
Quiet, on the other hand? Makes me feel... lied to. As though I'm not even deserving of a truthful answer. If she really breathes through her skin, how come she has an optional outfit that covers her entirely? Answer: because it's bullshit, and Kojima couldn't just be proud of his liking for girls with big tits. If Miranda had been telling Shepard her biotics only worked if her outfit clung to her every curve, I'd have been MUCH more pissed than them just laying her out there with her lovingly-sculpted arse speaking for itself as to why they made her like that.
I guess I can understand some women feeling like female characters are being objectified instantly the second they're given big boobs, because not everyone is born with them, and it IS done to entice players. But to me, I've never minded as long as people didn't try to bullshit me. Though for all I know, that's because it's more normal to me because I'm not exactly small myself.
I would like to hope we live in a world were honesty is more important than possible sales garnered through PR bullshit.