I would like Fallout 4 to take place in NY, New Jersey, Europe, Russia or China. It'd be a different perspective and might add more to the story of the apocalyptic war.
2 things I want changed. Get rid of that awful chance shooter b.s. I don't think anyone has the time to stop and think about what body part they can hit most effectively and most likely... not too mention how aggravating it is when you miss and you just spent half your day zooming in while time stopped in order to give you statistical analysis of what you should do in, what would usually be, a split second. It's so boring and unrealistic to reaction time that my eyes want to scream at me for torturing them. I know you don't have to use it, and I don't, but the game seems centered around it.
Secondly I would like to think that a point blank shotgun blast to someone's cerebral membrane renders them with an incurable case of death and not just a critical wound. I mean, most of the time I'm running backwards from a guy who's head is "critically damaged" and yet he's still chasing me at full speed, keeping balance and managing to fight back quite effectively. I understand that, say, mutants might take one more case of lead to the head but shooting a human in the head 7 or 8 times renders false. It reminds me of that hilarious part in Me, Myself and Irene where J.C. has to kill a cow... it's hilarious because it's so unrealistic! If the guy I shoot is wearing an armored mask, at least make it so that he's in shock or wounded. A face full of shrapnel is not the same as grazing your knee (unless you're 3, in which case every pain you feel is accompanied by a large whine until you're given ice-cream). This is a post-apocalyptic world, they don't have ice-cream. They just have brown, destroyed scenery, immortal men and useless guns!