Return to the West Coast, and perhaps even a look at the rest of the world. A choice of different upbringings with different main quest storylines (e.g. Vault Dweller, Tribal, BoS). Use of vehicle fast travel and random encounters (though this has been modded into the Fallout 3 now) Bring back traits!! Make it bigger, make it better!!
P.s. many of the things you guys are asking for are available in mods for Fallout 3
P.s. many of the things you guys are asking for are available in mods for Fallout 3