Not all video game quotes, but here we go.
"We are Pain. We are God." - Pain, Naruto
Deus: No, you can't... I can't die! Not now! You don't have the right! I'm Deus! I am a god-
Garrus: Yeah, well, I'm an atheist. *blam*
- Garrus and Deus, Mass Effect: Interregnum fanfic
"So, Haggard had pretty much singlehandedly invaded a neutral country. Not the best move." - Preston Marlowe, Battlefield: Bad Company
"I have no idea why she spontaneously decided to exterminate the local Gazelle herd." - Stinthad, Let's Play Dwarf Fortress: Reveredtour
"Your forefathers wisely set aside their compassion. Steeled themselves for what needed to be done. I see now why they left you behind... You are weak, and Gods must be strong.." - The Prophet of Truth, Halo 3
"We impose order on the chaos of organic evolution. You exist because we allow it, and you will end because we demand it." - Sovereign, Mass Effect
"Rise and shine, Mr Freeman... Rise, and shine. Not that I wish to imply you have been sleeping on the job..." - G-Man, Half-life 2
"This is the Garden of Kadesh. For thirteen generations we have protected it from the... unclean." - Kadesh Ambassador, Homeworld
"The Imperium. How mighty its aspect! How far-reaching its boundaries! As one world dies ten more are brought into the fold. Fear us, for we count the lives of planets, not men!" - Anonymous, Warhammer 40,000
"This is gonna be a real clustercuss for all of us." Mr Fox, Fantastic Mr Fox (that film was so clever...)