Honestly, I don’t think it would. Depp’s Grindelwald doesn’t seem like the kind of handsome and magnetic man that would fascinate someone of Albus Dumbledore’s caliber. Madds Mikelson on the other hand, strikes me as a much more plausible vessel for that.Even though the movie was likely going to turn out bad for a whole host of other reasons, losing Depp was really crippling for it. His presence would have at least lifted the movie from an F to a D. Still bad, but at least better
Besides, the movies are uniformly garbage and the ever increasing bullshit that surrounds Potter and friends is not the sort of baggage Johnny needs to be carrying around.