The ones that you enjoy. Pick what suits you, not what everyone says makes you the most powerful.
My one skill that I hate to be without: Repair. Because Jury-Rigging is a godsend.
Other favorites:
-Survival. In New Vegas, you can heal a ton with food. And this helps in hardcore mode as well. You'll still have the stimpacks for when you need them in a pinch, and you'll probably end up saving more of them this way. I just love playing as a survivalistic, self-made man
-Guns. Seems classic. A lot of the guns have a nice story behind them as well.
-Unarmed. Probably the most fun to use. And there is a perk [http://fallout.wikia.com/wiki/Piercing_Strike] that basically turns you into a Deathclaw.
-Speech. Because a little diplomacy is always nice.
-And a "loot" skill: Either Science or Lockpick. These let you into places either by hacking terminals or picking locks. I usually go with Science since it comes in handy in other ways as well.
My one skill that I hate to be without: Repair. Because Jury-Rigging is a godsend.
Other favorites:
-Survival. In New Vegas, you can heal a ton with food. And this helps in hardcore mode as well. You'll still have the stimpacks for when you need them in a pinch, and you'll probably end up saving more of them this way. I just love playing as a survivalistic, self-made man
-Guns. Seems classic. A lot of the guns have a nice story behind them as well.
-Unarmed. Probably the most fun to use. And there is a perk [http://fallout.wikia.com/wiki/Piercing_Strike] that basically turns you into a Deathclaw.
-Speech. Because a little diplomacy is always nice.
-And a "loot" skill: Either Science or Lockpick. These let you into places either by hacking terminals or picking locks. I usually go with Science since it comes in handy in other ways as well.