There will always be those that need incredibly up to date tech specs to enjoy their games. Yes, the WiiU will most likely be outperformed in this regard by the PS4 and Xbox 720, but I sit firmly in the crowd of "I don't give a shit."
My biggest concerns are the comfort and price of the controller. Surprisingly few people seem to be mentioning the fact that the analog sticks are ABOVE the d-pad and buttons, but this may be a simple adjustment. The buttons also look kind of small, similar to the DS lite's buttons, but it's hard to tell without seeing it in person.
While E3 isn't over and many of these issues may be proven non-existant in the next couple days, I'm going to list everything I can think of anyway.
Lack of GC controller ports: Considering how often GC controllers are used in Wii games like Brawl, Mario Kart, and many others, the console needs to be compatible with them in order to provide true backward compatibility.
Connectivity: I know they may have thrown that word around, but I think everyones looking for a real way to communicate and play with their friends similar to XBL or PSN, and we didn't see that today. We did see video chatting though....