in real time? i think cazadors are worse, they are small spammy creatures with their venom, and usually travel in packs that swarm your ass, while deathclaws all you need is a decent gun and have to shoot straight, and they are dead, granted they are fast as hell, but as long as you see them first you'll probably take em down.
if you can pause and use your AP points, then yeah, just shoot the cazadors wing off with a well placed shot, then they are easy pickings