For games where certain gear sets are better(WoW and MMOs in general), whatever is better for the class I play.
For other RPGs, I tend to base my equipment selection on what the character starts with. For example in FF5 I started Bartz out as a knight, Reina as a mage, Faris as a thief, and Galuf as a monk. And once one of the plot twists happens, I make that person into my healer, while basically leveling everyone else as the improved version of their starting "class"
If it has anything to do with choice, in games where "any build can be viable", I usually choose fast hitting melee with some ranged power. (for example: In Demon's Souls, I have a one handed sword, and magic. Stab, block/roll, magic, repeat)
Overall I prefer fast attacking, it looks a lot better than the slow, heavy blows (though those can look downright painful)
Funnily enough, when I payed WoW I mained a Death Knight, while I normally enough rogue type characters. I couldn't stand them in WoW.