I like zombies, I would like to see more and better Zombie games, but I digress...
What I would like to have as antagonist is pretty easy, something society finds cute and innocent.
Let's do a game where you can viciously maim, crush, decapitate and slay children. Those annoying toddlers are too cute for you? Well how about teenagers then? They are smelly, angst ridden and they come in different flavors: nerd, bully, broad, geek and emo. Butchering them would really be quite stress relieving for a change. Don't you think?
If that is still not political correct enough for you feel free to be offended, but I have another proposition, we could enjoy another slaughter fest of something cute, pervertedly popular and innocent.
How about a game where you have to stop the invasion of the "friendship-rainbow-ponies" which try to mind-f*ck and enslave humanity with their "friendship-hyped internet phenomenon" methods while you, the main manly but slightly homophobic and mysogenist protagonist are one of the last unaffected - immune to their effects of mind control and thus you embark on a quest to butcher, flail and burn every freaking blinking rainbow pony you can find.
That would be very satisfying. People could use this to relieve stress, violence against children (and ponies) would decrease and everybody would be happy.