Holding up the flag for Deus Ex 3.
Yes, it's always stupid to hold up hopes for franchises whose sequel already trashed itself spectaculary, but if they keep up that design, are capable of keeping the choice-system as good as it is now, bring back an augemntation-system that really feels like something character-defining AND provide an interesting plot...too good to hope for.
Skyrim is quite possible, though after Oblivion...and it's really close to grinding the same thing to death, given the number of programs and the timespan in which they appeared.
Portal 2, despite everything, is the least likely to be THAT game, at least in my eyes. As Yahtzee said "Yes, it's only 3 hours long, but that's a good lenght for it." It just reeks too much like bland franchise-milking to me, and hands up for everyone who sees "The cake is a lie"-jokes and at least two "Still alive"-songs coming.
Though it'd be poetic if Portal 2 became the biggest Portal-jerk off of them all.
As for ME3 and SW: TOR.....yeah...the latter one probably sacks it for being the "new" Star Wars. And for both goes....I think I kinda see the path Bioware is walking down right now. Proove me wrong, but DA 2 and the TOR-trailer are so going along with my fears in that matter...