If the expedition is properly organized, why not. That means big installations, the ability to cultivate plants indoor and so on. Pretty much like the same you see in big spaceships in science-fiction, only on a planet.
Unfortunately, it'll be decades before we can send that kind of payload. We'd probably have to build an advanced station on the Moon, or simply build the necessary ships directly in space. For this we need very cheap means of transportation from earth to its orbit. That means space elevator (we know how to make the cable, but not how to make it more than a few meters long), or space planes, much like Virgin Galactic's.
So in the end I think that question will be relevant in about 20 years at best.