My PC is... problematic. It always needs 2 tries to boot up (what happens the first time varies. Somtimes a BSOD, or hanging, or booting windows but crashing every game I try to play), and every few months it cuts out completely and I have to reinstall windows. My games are on the D: disc, so the game files are not deleted, but they no longer count as installed, and some games won't let me copy the save-folder into the new install. Most annoying instance: Mount&Blade Warband (I took care to copy the save file, but he doesn't recognize it post-install). Had my own kingdom with 4 cities, high level and probably a few dozen hours clocked. I haven't bothered starting a new game.
Oh, and a long time ago, when playing Black & White I had just completed the tedious mission where your pet is captured, the new mission begun, my headquarters was being built... and I dropped a rock on it. I didn't have enough resources to build it again, and didn't have enough god power to pick the trees. The game autosaved this situation, so quiting the game and starting again just put me in that state. I had older save games, but because a menu screen killed Peter Molyneux's father or something (see also Fable III), the only way into the load-game screen as opposed to starting the last saved game had to be done by entering the headquarters I didn't have. That did it for me for that game,
