My Fem!Shep romanced Liara, the pay off to staying true to her was amazing.
Garrus and Tali hooking up was a nice touch, but ultimately I best connected with Tali on Rannoch when she sat on the ground and breathed the air of her homeworld for the first time.
"There is no Shepard without Vakkarian" that combined with the ultimate bro moment (even as a Fem!Shep) with the rifle and the bottles, cemented without a doubt who Commander Shepard's best friend was, and his name was Garrus.
"Shepard, you've been a sister to me" Oh Wrex, you big softie
"Someone else would have gotten it wrong......" I miss you Mordin
"Does this unit have a soul?" Yes you do Legion, yes you do.
Grissom Academy was also a welcome moment, saving David and Jack, who has gone from damaged phsychotic to a teacher: there is no greater victory for her over Cerberus than to move past what they did to her, and make sure it never happens again.
The game is filled to the brim with awesome, heartwarming and tearjerking scenes. I never wanted the ending to be farting rainbow bunnies, and as I hobbled towards the transit beam I thought "This is it, like many before you, it is time to lay down your life so that others may live". The ending wasn't just bad, it was hollow and frankly unworthy of a game that until that final twenty minutes, had been as close to perfect for me as any before or since.
CAPTCHA: the bee's knees.....it really was.