I trust Trey Stone and Matt Parker with something like this, because, for all the rude, crude and questionable content of South Park, they never really preach hate. Cartman is explicitly the Worst Person Ever, and on top of that, his hateful remarks are pretty clearly based on ignorance (often wilful ignorance, but I digress).
Actual jewish characters, meanwhile, are presented as reasonable human beings. Kyle isn't always the nicest person, but he's generally pretty reasonable and rational. So yeah, I don't see a problem with this, because I would assume that the class would be more a parody of Cartman's opinions than of Jews as a whole.
This article, however, only betrays that apparently Greg Tito thinks that if he makes a non-joke about the holocaust while talking about Trey Stone and Matt Parker, everyone will think he's as 'Edgy' as they are. Or maybe he genuinely thinks the Holocaust is hilarious enough to carry a joke on it's own.
Or that Jewish people complain about it too much? This just makes me uncomfortable, ugh.
Whatever. Game looks funny, will wait and see if it plays well.