i'm really showing my age here but mine was Ghostbusters for the Commodore 64, the start game screen blew my mind back then. a cheesy 8-bit instrumental version of the ray parker jr. theme would pipe out through the speakers and when you pressed the space bar it would activate a really rough 8 bit sample of some guy shouting "GHOSTBUSTERS!!". Me and my older brothers wasted hours mastering the art of pressing the space bar just at the right moment to get the sample to play in perfect timing with the theme song.
this was a feature sadly missing from the sega genesis and xbox 360 ghostbusters games. you younger folks may think that makes me a sad bastard but if you're a ghostbusters fan it beats the crap out of bullet time, rag doll physics or realistic debris effects for entertainment value hands down! used to hang around the arcades a lot in those days too, wasted a lot of loose change on operation: wolf, which was a shooter that played out pretty much like the last 20 minutes of "commando", sadly you didn't get to throw a pipe through a baddie in a boiler room and tell him to "let off some steam".
ah the 80's, such simpler times, sure the graphics were shite and the controls were broke as all hell but at least then you could play a game with a higher body count than saving private ryan without having to worry about media controversy