Assassin's Creed 2 in the beginning (relatively). First, they don't explain the controls much, thankfully I did just finish playing AC 1, so that wasn't a problem but it still bothered me. Second, the Italian accent was really annoying - I would have preferred if the game was entirely in Italian or entirely in English - the Italian accent seemed retarded to me. And the worse part is that from time to time the characters would slip into Italian for no apparent reason (aside to reassure me that they were indeed Italians). Then, I had to meet "Leonardo" - I was actually praying to not be Leonardo DaVinci because I didn't want the game to just name drop me and make me feel impressed with it. No, at that point I would have been more impressed, if the painter Leonardo was somebody else. Finally, you get yo meet your uncle...and one of the first things he has to say is "It's-a me-e, Mario!". I rage quit at that point. It was too much. I had wait until the frustration went away to be able to play again.
Thankfully, with time it got better but I was literally on the verge of not bothering with the game any more. I got used to Leonardo and the name dropping, so much that when Machiavelli showed up I didn't feel anything. Italian accent was still annoying, though.