On further rumination, I'd add one more big one.Eacaraxe said:Just the tips:
...keeping companions up to snuff...
...Dodge is godlike...
...Weapon skills don't give that great an RoI, especially early on when the tech, stealth, and dialog skills are at a premium...
...keep weapons and armor tinkered...
Respeccing your character isn't just for build and level-up oopsies, it's cheap, and it's doable on-demand. Buy early perks if you so desire, with the intent of respeccing out of them later once they lose their value due to natural progression and/or are rendered entirely obsolete by later perks.
Resilient, for example, is one of the better perks at tier 1 while you're still early in the game. Even better than Toughness in my book, since we're talking about a static boost to a small health pool due to low levels, versus five damage off every incoming attack at a point that alone can double or triple effective health. When you're in the teens and armor regularly clocks in at 20+ rating, especially if tinkered, you should look at swapping Resilient for Toughness. Negotiator and Few Bits More are in the same category: they're excellent at low levels when you're still hungry for ammo, shunts, or mag-picks, but lose their usefulness by the time you get to Groundbreaker or your first couple stops past it.
Meanwhile, Quick and the Dead is an invaluable early pick. Faster TTD regeneration is great. But, once you unlock tier 2 and get access to Reaper, innate TTD regeneration loses its premium status since you can regain TTD by killing enemies -- and you'll likely regenerate TTD in combat just as fast if not faster with Reaper anyways. With Reaper, Slow the World becomes more important since more seconds' worth of TTD gets you more of a valuable commodity all while improving Reaper's RoI.
Run and Gun is in the same category for high mobility characters. It's fantastic, until you unlock tier 3 and get access to Steady Hand, at which point the RoI for the later perk invalidates the earlier purchase.
The big takeaway here, is to buy what you need when you need it, then simply respec later when better perks become available. My recommendation would be to respec at 12 or 14 to offload deprecated perks in favor of better tier 2's, then again at 22 or 24 to do the same with tier 3's.
Also, Temperament is pretty much the one stat to rule them all. It scales, and unless you drop some serious skill points into Medicine your passive health regen will match the inhaler's if Temperament is Very High or Maximum. But, the biggest not-terribly-obvious bonus to high Temperament is the ability to unequip Adreno and load up on nothing but buffing consumables.