The 2010 remake (reboot?) of Splatterhouse. I only made it to about the third chapter when I was about done with it.
The difficulty was all over the place, the combat was incredibly repetitive, and not even the awesome voice work of Jim Cummings was enough to pull me through to the end. No, the real stinger was the atrocious cutscenes. Allow me to explain: each and every time you die (and take my word for it, you do this a lot), you are forced to endure an agonizing 15-20 seconds of the ugliest monsters snarling and growling as they fight for screen space. It isn't even as if there are variations of this, oh no: it is the exact same animation looping over and over again.
That, along with the loopy, woobly camera shaking that goes on during these loading screens, I was getting headaches, fast.
So yeah, fuck that game hard. I wasn't going to deal with that anymore.