There are concerns that the dust found on the lunar surface could cause harmful effects on any manned outpost technology and crew members:
Abrasive nature of the dust particles may rub and wear down surfaces through friction;
Negative effect on coatings used on gaskets to seal equipment from space, optical lenses that include solar panels and windows as well as wiring;
Possible damage to an astronaut's lungs, nervous, and cardiovascular systems.
The principles of astronautical hygiene should be used to assess the risks of exposure to lunar dust during exploration on the Moon's surface and thereby determine the most appropriate measures to control exposure. These would include for example, removing the spacesuit in a three stage airlock, vacuuming the suit before removal, using local exhaust ventilation with a high efficiency particulate filter to remove any dust in the space craft's atmosphere etc (Ref: Dr J R Cain presentation "The application of astronautical hygiene to protect the health of astronauts", UK Space Biomedicine Association Conference 2009, Downing College, University of Cambridge).
The harmful properties of the lunar dust are not well known. However, based on studies of dust found on Earth, it is expected that exposure to lunar dust will result in greater risks to health both from direct exposure (acute) and if exposure is over time (chronic). This is because lunar dust is more chemically reactive and has larger surface areas composed of sharper jagged edges than Earth dust (Ref: Dr John R Cain, "Moon dust - a danger to lunar explorers" , Spaceflight, Vol 52, February 2010, pp60 ? 65). If the chemical reactive particles are deposited in the lungs, they may cause respiratory disease. Long-term exposure to the dust may cause a more serious respiratory disease similar to silicosis. During lunar exploration, the astronaut's spacesuits will become contaminated with lunar dust. The dust will be released into the atmosphere when the suits are removed. The methods used to mitigate exposure will include providing high air recirculation rates in the airlock, the use of a "Double Shell Spacesuit", the use of dust shields, the use of high grade magnetic separation and the use of solar flux to sinter and melt the regolith (Ref: Dr John R Cain, "Lunar dust: the hazard and astronaut exposure risks", Earth, Moon, Planets DOI 10.1007/s11038-010-9365-0 October 2010)