I'm not going to say that Yahtzee didn't get the game because honestly every single person takes something different away from the game; however, I feel like he was looking for the wrong things in Issac's occasional interactions with Nicole. They weren't intended to create empathy with the character, they were intended to make you question whether or not Issac was hallucinating. The idea that an unarmed girl could survive alone on the Ishimura when trained military professionals were slaughtered makes no sense, especially considering that she seems to just walk out of the room without worry whenever you see her. Issac's lack of emotional reaction is more of a sign that on some level he understood he was fooling himself. And he was characterized, just never verbally. If you read his notes on each objective, you got a clear sense of who he was as a person-- utilitarian, logical, and level-headed. Which is precisely why he survives when others die.
Also, his comments about the level design being cliche strikes me as odd. You can clearly see a practical theme to everything. And the gothic influences are astounding. You can see an amalgamation of old architecture and science fiction. I mean, a ship with influences clearly derived from flying buttresses? How is that not original?
Also, even though the story is cliche the religious overtones provided by the unitologist add a lot more depth than the standard sci-fi horror story contains. The obvious criticisms of accepting everything on blind faith and inadvertently worshiping the necromorphs as almost god-like because they have a relation to the marker, when in actuality the marker is meant to contain the necros? That's at least somewhat interesting on a story-telling level and it was certainly never explored in Alien/Aliens or Event Horizon.
And the game throws out a number of small treats for people who really paid attention. For instance, read the first number of each chapter. *SPOILERS SPOILERS SPOILERS* Nicole is dead *END SPOILERS* Or the fact that in one of the middle chapters there is a sign scrawled with what looks to be a method of translating the alien symbols written on the walls throughout the entire game. And if you actually take the time to write down the method you can go back and translate every little bit of scrawling in every level. I doubt a generic game spewing machine would add that kind of detail.
I do have to say though, while Issac's silence may have had some interesting connotations on his interactions with Nicole, it certainly makes the opening scene seem incredibly awkward. The kinesis and stasis guns also feel incredibly shoehorned into the game and that the pacing never really hit its stride, but as a whole I'd have to say that the game is incredibly well done and does not feel generic in the least.
Final Note: Zero punctuation is the last review source I really trust, and I seem to have the exact same taste in games as Yahtzee because this is the FIRST review I have disagreed with.