It's so disappointing when a story takes a good concept and doesn't take it to ALL its logical conclusions. Why does every story with telekinesis just have people lifting heavy things or people? Why not use it to pinch a person's nerves, thereby paralyzing them with pain? The best works are those that explore their gimick, not just retred old ground.
A non-video game example: the manga Embalming: The Another Tale of Frankenstein (and no, that's not a typo, it's just that engrish a title). Instead of just having dudes fight a bunch of monsters cobbled together by Doctor Victor Frankenstein, they had him be decades dead but his research available to the black market. Consequently, you have monster makers all over the world and using the research as a jumping off point for all sorts of insane, awesome frankenstein creatures.
It's a great series because it not only uses the idea of stitching body parts together to create the random monsters to fight, but it sets the world up so that the forms they take are limited only to the imagination. There's even a frankenstein made with an entire village's worth of bodies strung together into one. Why? Because the creator was a crappy monster maker, something which could never be the case if there was only one guy making the monsters because by necessity that one guy couldn't be so incompetant and yet also make so many dangerous frankensteins well.