Hmmm, the only thing that surprises me here is given the focus on hand to hand combat (to begin with at least) it's not being compared to say Yakuza as opposed to GTA. I haven't played it yet, but from the descriptions it sounds a LOT more like Yakuza than GTA, especially given the mention of mini-games like Karaoke.
That said, having seen what they did with City Of Heroes/Villains and Champions Online, not to mention games like Prototype and Infamous, I've been waiting for a single player third person sandbox RPG based around super heroes where you can create your own character and select powers and such as opposed to being handed a guy with electricity or bio powers and told "play this". Basically the hero MMOs, but with the depth that you only get from a single player gaming experience.
I'll also say that "Saint's Row" seems to have taken the sandbox insanity crown, where "Grand Theft Auto" has gone in the "realistic" direction. That said while you have jet bikes in SR 3, you don't yet have Jet Packs. I'll also admit that they kind of ruined a lot of the insanity by making the world a bit too silly, as many have said, the insanity works best when the world plays straight man for you (so to speak).