I'm a little torn about this, part of me wants to sort of defend it as I think all humour should be fine, whether it offends or not.
However, without having seen the show or knowing anything about it, I'm going to guess it was packed to the rafters with manhaters who whooped, clapped and cheered the line. Part of me is being lazy and assumes it's a US version of 'Loose Women' where about 4 middle aged harpies ***** about stuff and blame men for everything while at the same time transparently lusting after any male guests who look nice.
Now for UK escapists, lets do a parallel universe, where Frankie Boyle is still on Mock the Week and does an edgy line about sticking a power drill up Katie Price to stop any more kids falling out.
While the 'joke' is about as offensive, you can bet the audience would laugh, but, reservedly, the reaction you'd get from a rape joke or gag about a recently deceased celeb.
For example, when the Top Gear guy nearly died in a racing stunt, and was still in hospital, Boyle made a joke about a 'safe driving advert' that showed him in a hospital bed trying to remember his wedding day. There were some sharp intakes of breath and a lot of 'oooh that's a bit far'. There were no 'ha ha, yes I hope he dies too'.
To me, it's the audience reaction that makes it wrong, and the knowledge of the reaction is what made that woman decide it'd be fine to say it.
I'm fine with the male gender constantly being the braindead, incompetent sexcrazed yet incapable halfwit that is depicted on most TV ads, sitcoms, etc. After all, we've had it our way for a long, long time, in the battle of the sexes.
However, when they try to push that to 'men are so evil that we should be allowed to violently mutilate them' it's too far.
In short, I'm not daft enough to demand equality for men, we've had it our way for far too long and it's fair that women get a few perks now. What's wrong is to decide nothing is taboo so long as it's anti men.
Just as an aside, why do these man hating shows, magazines etc ***** about men for half the time and spend the other half showing you what you HAVE to do, if you're ever going to get Mr Right?