Certainly. It's usually a case of not having a diverse enough set of game mechanics and/or environments to keep the game interesting in the long run.
Such as Doom II and Unreal both wore me down. I've played other 32 level Doom games and thoroughly enjoyed them, but Doom II just got repetitive as it wore on. The original Doom had about the same number of levels, but split it up into four different episodes, so you didn't spend the vast majority of the game maxed out on weapons and ammo. Just didn't like the pacing of Doom II.
Unreal's combat is a bit too slow paced for me, so trudging my way through its large levels wore on me more and more as the game went on. Afterwards, I played the add-on pack, which was about half the length and rather enjoyed it.
I also thought Wanted: Weapons Of Fate was too long... at six hours. First four or so hours were quite a bit of fun, but near the end, it just padded out the fights too much and it became a trudge. I was happy to see the back of it.
In my opinion, if someone says a game is too long, it's really an indication that something else is wrong with it.