Halo 1, Master chief: "We'll be fine."
It's nearly at the start of the game and really sums him up and how you yourself feel during the entire game, the marines and even Covenant might panic at times, but you will be cool and collected through it all, because you're the damn chief.
Battlefield 3: *groans* *hand reaching towards a blurring sky*
I die a lot.
Dragon age 2, Merrill: "Everything affects everything. We were born, a bunch of things happened, and now we're in a mess with our friends."
I actually liked the game, and this statement during party banter pretty much sums up what has been going on for the past nine years... :-D
Batman Arkham city, random thug: "I'm going to kick your-argh!"
I just feel as such a badass being batman, interrutping the thugs by breaking various bones in their bodies...
Mass effect, Sovereign: "You exist because we allow it, and will end because we demand it."
Works for both games actually, those arrogant Reapers just ticks me off! They must die!