Depends. If we're dealing with people who support racism or sexism for any reason, but especially stupid vacuous ones, then yes, I hate the motherfuckers. I hope a tornado hits their home.
If it's a discussion on whether SMT: Nocturne was a fantastic game (YES IT FUCKING WAS), then no, I won't hate them. So long as the opinions aren't ones that actively support damaging things, it's all good.
I do hate people who say that opinions can't be wrong, though, because that's not true. Preferences cannot be wrong (though they can be rooted in damaging ideology); opinions can totally be wrong. Example: I'm of the opinion that iPhones make the best cat litter. People have plenty of opinions that are easily proven as being factually wrong. On the other hand, someone saying "I'm of the opinion that grilled cheese sandwiches are best with a slice of tomato," is stating a preference, since it's a matter of subjective taste. Just because the word opinion was used doesn't mean it's not a preference. However, if the person says "I'm of the opinion that every person that doesn't eat a slice of tomato in their grilled cheese ought to be buried alive," is obviously reaching a faulty conclusion if you talk to anyone sane.