In self defense AND they are actually a threat, like they have a knife or have some weight behind their attack. Most girls... If I was to hit them back after they hit me I would destroy them with a single motion, generally the act of restraining a girl after they've gone crazy takes very little effort on my part and leaves bruises just from the pressure of my grip.
There is something to be said for man code and male pride.
"No man shall fistfight a woman. This is a lose-lose situation. If you win, you're a woman beater. If you lose, it's the end of your manliness. Even women deemed honorary men are off limits when fighting.
Caveat: If a woman hits a man like a man (hard, in the face, with a closed fist)she should expect to be hit back like a man. The retaliation is limited to one(1) blow. The woman's initial attack must be witnessed by impartial individuals or mutual friends. If the man taunts the woman into hitting him, the rule does not apply. This rule is VERY dangerous to invoke, as your manliness is in serious jeopardy if utilized incorrectly.
On a related note, it is also wise to avoid any manly games against a woman.(Drinking games, arm wrestling, etc) When you compete against a woman, your manliness will be permanently tarnished if she wins. The exception to this rule is when a man purposely loses in order build self-esteem in the woman with the intended goal of sexual activity later in the evening.
A man can never win a fight that he started with a woman. A man can never win a fight that he didnt start with a woman."