I'm waiting to see how this turns out, but I'm cautiously optimistic. I already prepared and expected for the game to be made more, I hate to use the term, but casual in terms of mechanics, but this looks like it could be a nice middle ground. I don't think there was anything particularly good about Fallout 3 and New Vegas's approach to leveling and skills, I mean, several skills could very easily be translated directly into perks, I'm looking at you Lockpicking. It was only with a decent amount of modding and the introduction of several additional features in New Vegas, primarily crafting, that made Skill expenditure more meaningful.
HOWEVER.
There are a few really big flags so far that I've seen that make me extremely cautious to this new system. Not because the concept of it is bad, but because Bethesda has made poor design choices. I preface this next statement with it not being an issue with sexuality within these games, but more how it is portrayed through design choices.
Bethesda has already proven to be massively out of touch in some areas of character design to me that has only been further cemented by this. Namely, the predetermined backstory forcing a set narrative onto a character that should be left far more open to the player, and the apparent removal of two of my favourite perks from New Vegas, Cherchez La Femme and Confirmed Bachelor. In the video, scrolling through the Charisma perks, we can find the equivalent of Lady Killer once again. The issue I have with this is that it appears to remove both of these perks that present homosexual options in game. Personally, I've never really used either of these, but the inclusion and opportunity of each was great, gave the opportunity to add a lot more flavor to your character and how they interacted with the world. Bethesda's approach to this so far appears to be the exact same as the one they took with Skyrim, by making every companion romanceable and thus bisexual. I feel this essentially neuters each of them from the start by making gender irrelevant to them, and removing the ability for having meaning given to a character through sexuality. I mean, give us a lesbian character, a couple that are gay, and maybe a bisexual one, and it'd be great, because it could play a larger roll in each character instead of just glossing over far more potentially interesting distinctions and traits.
Wow that got ranty.
tl;dr
System itself looks fine, cautiously optimistic, however it looks like Bethesda is openly ignoring good improvements to game design done by Obsidian because Bethesda still hates New Vegas.