My first character was just for shits and giggles. I did some stupid random spread of stats, I think charisma was low and strength was high, and I tagged guns, lockpick, and sneak, thinking I was going to play it like FO3. Then I turned into the ultimate "assertive" cannibal merchant. I had all the merchant perks, I got cannibal and got all the perks associated with that (including the one where you have to eat Mr house, caesar, the king, and president kimball, Im really rather proud of that). I primarily used the riot shotgun, the all american, and a silenced sniper rifle. I ended the game by taking over Vegas with yes man, devouring legate lanius and the general guy because they were both dickheads, and had my pockets lined with 215,000 caps.
My new guy I'm making is going to focus on hi-critting energy weapons and a stupidly overpowered chainsaw (and yes, I know that doesnt make any logical build sense) so I can go texas chainsaw massacre on everyone in the strip because I'm siding with the legion this time around. I will be feared!
PS: Props to the pulse gun, that little pistol made fighting all the robots the first time around a breeze. I always had it on me, at top condition.