I imagine that the problem is less about actually making friends, and more about finding a situation where talking to people you don't know isn't horribly awkward. At school you can talk to people in your class, at work you can talk to people there because you have a shared social experience to talk about, regardless of anything else.
A good way I've found is meetup groups, via the website meetup.com. There's all kinds of interest groups that meet up and have a good time. I haven't made any incredible friendships by doing so, but I have had a lot of fun. That or find a place that shares your interests, comic book store maybe? and see if they do events. Hell, you could even use this forum. Create a topic saying "CITYNAME escapists, let's meet up for a drink!" and see if you get any responses (note, if you do this, make sure its a public venue that people can find, and has numerous exits in case you need to flee the dreaded forum lurking serial killer. Just kidding... OR AM I?!)