The following items are often preceeded with "The"
As far as SHOTGUNS go? I have a list.
-Butcher Mk II: Soldier of Fortune Shotgun
-System Shocker: Mass Effect 2 Geth Plasma Shotgun
-Lightshow: Fallout 3:The Pitt Metal Blaster
-The End: Fallout 3 Experimental MIRV
Other firearms also has a list.
-One,Two,Three!: Modern Warfare 2 FAMAS,with Thermal and Silencer
-Brain Pick: Mass Effect 2 Mattock (Cookies if you get where the nickname comes from)
-You Suck: New Vegas YCS/186
-Sasha: Team Fortress 2 Standard Minigun
-Carl Gustav: Team Fortress 2 Direct Hit
-God Gun/Zeus Cannon: Crysis:WARHEAD PAX
Melee weapons? Again,a list exists.
-Zweihander: Any mundane two-handed sword
-Big Stick: Any mundane two-handed plunt weapon
-Can Opener: Fallout series Ripper
-Black Death: Minecraft:Equivalent Exchange Mod Dark Matter Sword
-Planet Fire: The front bumper (If you understand THAT reference without google,I will respect you greatly)
-Backwards Gloves: Team Fortress 2 Fists of Steel
And finally,a list of my favourite RTS weapons with my associated nicknames.
-Authoritative Asskicker: Supreme Commander 1 Cybran ACU with Microwave Laser generator and personal stealth
-Everything: Supreme Commander 1 UEF Fatboy
-Kill Switch: Supreme Commander 1 UEF Mavor
-Locust: Supreme Commander 1 any T2 gunship,especially the Cybran Renegade (AoE weapon)
-Demonic Spider: Supreme Commander 1 Cybran Monkeylord
-Indy: Dungeon Keeper 1 Boulder Trap
-Murder Lady: Dungeon Keeper 1 Level 10 Mistress (Speed+Lightning+Drain!? Oh,my...)
-Bringer of Light: Command & Conquer Generals Nuke Cannon
-Plan B: Supreme Commander 1 any T3 missile sub
Quite the extensive list. I,personally,think the names are appropriate. What about you?