So, here's my theory about this. To help illustrate, here's a picture of the standard "uncanny valley" chart.
http://2.bp.blogspot.com/_L_GZ4wQqOPw/SwQHvDTHgrI/AAAAAAAAAJ8/YdR1da1cA9w/s400/uncanny-valley1.jpg
For those of you saying, "Sorry, I'm not into anime", my theory is that people experience the "uncanny valley" effect differently. Whereas some people would put anime characters somewhere in the deeper parts of the valley, people who find anime characters appealing would place them somewhere around where "Disney Features" is indicated on the red curve, near the first peak.
This is clearly illustrated by whoever drew the red curve on this variant of the graph, placing Final Fantasy nearly at the bottom of the curve. Harsh, unless maybe the author was referring to the ill-conceived Spirits Within movie, in which case I can see their point.
However, even anime fans would find OP's pic creepy, and that's because real-life anime girl is going in the wrong direction on the familiarity curve. If you add features of characters that are deliberately unlike a real person to an actual person, there's nowhere to go but back down into the valley. Exactly how far back "real-life anime girl" slides varies depending on the observer; I, for example, personally don't find her hideous or anything like that, but I find her appearance quite bizarre and unattractive compared to your average girl.
Full disclosure: I'm one of the people who likes how anime characters look.