As a man of numbers and the big picture, I'd sacrifice those closest to save the one with most numbers. Honestly, I'd hate myself, but I have to think about it:
Killing all those people will make you troubled, whichever button you press. For example, f you chose saving the few to save a lover, then your relationship is in serious jeopardy. Ask any couple that had a traumatic event happen where lives were lost. Most split up within a year from grief, and such. Lastly, I know all my 10 closest people would prefer it that way. Most of my family and friends are all military personnel or training to be, and understand the importance of risking one's life to save others. If I was one of the ten in the question, I'd prefer to be killed to save the hundred other in the next room. At least I wouldn't have to live with survivor's guilt, as I know they all would be.
And this is the Escapist we're talking about. Most never have a hard time killing off people inhumanely to save a loved one or themselves, yet are seriously against war, death penalty, violence, and the like. It's actually mind-boggling at times with such hypocritical views.