If I were to reboot Resident Evil, I'd make Umbrella an innocuous biotech company who accidentally made the zombie virus when they were, let's say, trying to engineer a viral anti-neurodegenerative agent. Instead of curing Parkinson's, they've made a tenacious little bugger that turns people into mindless, cannibalistic berserkers, with an emphasis on tenacious. They thought they destroyed all traces of the thing in testing after the obvious bugs reared their brain-craving heads, but just enough got loose, and now Raccoon City (or wherever) has been bitchslapped by George Romero. So, what does Umbrella do? It admits its mistake and asks for help as it desperately tries to make a cure.
In short, I propose making the virus itself the main antagonist, giving it, endurance that makes a cockroach look like a hothouse orchid and a viable lifespan that makes a sequoia look like a mayfly with rapid aging syndrome, and casting Umbrella as an organization capable of saying mea culpa and who then works to correct its errors. More believable behavior by the corporate guys, an excuse for an IN SPACE spinoff, and better rationale for sequels in general. Thoughts?