Better list than 10-6 (of which I only saw one even remotely worth considering.
First off, I am glad to see that I am not the only one who actually shows some respect to the Simpsons. I sometimes wonder if I do purely out of my own nostalgia and given Bob supports it unfortunately it makes a stronger case that I do. However as a reboot, maybe, but I dont see it being likely. As for its end It seems that the greatest likelihood is that its end is at hand. Once the completion of the 25th season It seems like it will finally be put to rest as it looked like fox only renewed it specifically to get to the quarter century mark.
Babylon 5, I am inclined to agree. While most of it does hold up right now we are in a MASSIVE sci fi drought. Battlestar franchise has wilted and dried to a husk, Starwars has essentially been forever ruined, Stargate tried its own reboot and actually made a better product but so alienated the fanbase it is essentially credited for killing the franchise. Then, It has been almost a decade since there was a TV centric incarnation of star trek that is its foundational roots, And the Abrahms films are little more than a shimmery regurgitation. The franchise needs to go into its true future in its predominant timeline, and make the same sort of historical jump made from ToS to TNG. (killing tangent here) Look at some of the sci fi options rolling around right now. Its an incredibly desolate landscape with fantasy taking a more dominant role at the moment with most notable occurrences being more in film than television. A Babylon 5 reboot could help revitalize this as a more enduring franchise, while trying to fill the void that new IPs like Defiance have no hope to fill. However there is a certain degree of logic here that might make the most sense for this franchise to jump from TV to film for such a reboot, and if THAT can generate interest, then begin working on ideas for a full fledged tv reboot.
Gargoyles I fully agree NEEDs a full fledged reboot, but the problem is that there is absolutely no purpose to do so with Disney still in control of it. For its time it was exceptionally dark and that was in MAJOR part to Batman: TAS as its prime competitor. But if Disney were to revisit the content that darkness would ONLY be diminished thus negating much of the point. If a truly mature incarnation could exist, that would be the best thing for that franchise, but its abundantly clear Disney would not dare go that far.
Harry Potter, I do disagree with its need or even the potential benefit. Essentially the whole purpose behind the desire could be accomplished by Warner Brothers specifically doing a "Edited for TV" Streamlined version that whittles each film down to its core elements at around 45 min to 1 hour and making it ideal for things like Holiday weekend viewings for TV. 17.5 hours down to a more manageable 8 hours could accomplish ones desire for "one sitting"
Personally I do not fear reboots or retellings if they are done logically and well. They can serve logical function especially in their proper role as more filler material to help support the more important original IPs.(such as in television programming blocks)
Other things in need of a do over.
Batman Beyond - Too much potential ended up squandered
Starship Troopers - The original was phenominal for its time but the people controlling the property seem like they are bent on gutting the franchise in the worst possible way (Although Invasion was a mild bright spot)
OR
Space: Above and beyond which might have been a knock off of SST, but at the same time it doesnt have the same baggage with its pedigree.
Star Trek: Tv Series - As mentioned above
Krull - Great universe that never got anywhere near enough exploration
Edit: Have a few others eluding me atm, May update later.