Look, in "Worms" you have guns that fire farm animals. You have, obviously, the BFG9000. You have the gunsword. You have the alien guns from the original Half Life and its expansion packs. You have the annelid launchers from System Shock 2. There are literally hundreds of examples that you could use.
But like L1250 I would refer to this:
L1250 said:
I keep trying to think of something from a game, but my mind always goes to this:
On the same subject, in the original Wolvenstein 3D you got to take on the firepower of a quadruple chain-gun. Wielded by Adolf Hitler.
And if that doesn't win the thread, I don't know what the heck will.