The only glitch that's really buggered up for me so far was one of the 'find a dragon shout' missions, given to me by the Greybeards. You know, the one's where they just add a marker to your map so you can go get a new shout.
They sent me to one I'd already been to. I was attacked by a dragon on arrival, which promptly failed to burn up after death, then the wall was still chanting away and fizzing, yet there's was no shout for it to give.
I couldn't remove the quest or mark it as complete, so I couldn't get any new locations from the greybeards.
No problem though, I'll just add all shouts myself, using the console.
Currently, I'm more bothered by the massive amount of disappointment I'm feeling over the end of the main quest occurring around 20 hours sooner than I thought it was going to. Great game........shitty main quest.